Ritonavir or lopinavir/ritonavir drastically improve plasma concentrations of oxycodone in wholesome human volunteers due to inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin greatly lessens plasma concentrations of oxycodone as a consequence of strong induction of CYP3A4.These medications are very powerful soreness relievers. It is importan

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